Programme d'impulsion Exposome

| Context

From birth and throughout their lives, humans are exposed to a wide range of environmental factors, including physical, chemical, biological, social, and psychosocial elements, all of which can affect health. Over the past two decades, the link between neighborhood or place of residence and health has become increasingly documented, highlighting how neighborhoods impact many dimensions of physical and mental health through chemical exposures (such as air pollution), physical exposures (such as walkability, access to green spaces and health/social services), and psychosocial exposures (such as social cohesion or violence).

In exposome research, the role of the social environment remains largely overlooked, although it should be considered central. The social environment may influence health through two main types of mechanisms:

• Exogenous mechanisms, involving external molecules, encompassing physico-chemical and behavioral exposures;
• Endogenous mechanisms, involving subjective interpretation and internal molecules, corresponding to psychosocial exposures.